Intestinal barrier dysfunction in SII mice.

<p>(A) The tight junctions observed with TEM in SII-Reb mice at day 5 and SII-Sal mice at day 5 and at day 10 were significantly damaged. The wider intervals (green arrowheads) between the intestinal epithelial cells were indicated. (B-C) The mRNA expressions of Zo-1 (B) and Occludin (C) in the small intestine of the 4 groups were shown (n = 6, *<i>P</i> < 0.05 when compared with Con-Reb and Con-Sal groups; ^&<i>P</i> < 0.05 when compared with SII-Sal, Con-Reb, and Con-Sal groups). (D-F) Protein abundances of Zo-1 (E) and Occludin (F) were indicated by Western blotting (n = 6, *<i>P</i> < 0.05 when compared with Con-Reb and Con-Sal groups; ^&<i>P</i> < 0.05 when compared with SII-Sal, Con-Reb, and Con-Sal groups). (G) Serum levels of D-LAC in mice of the four groups were shown (n = 6, *<i>P</i> < 0.05 when compared with Con-Reb and Con-Sal groups).