<p>PrP-d, disease specific aberrant PrP deposition</p><p>SMLN, submandibular lymph node</p><p>lgLN, inguinal lymph node</p><p>MLN, mesenteric lymph node</p><p>PP, Peyer’s patches</p><p>Temporal sequence of PrP-d accumulation in lymphoid tissues after i.p. rec-Prion inoculation (PrP-d positive samples / Total samples examed).</p
<p>MPI = months post-inoculation; CNS = central nervous system; Lymph = lymphoid tissues; IHC = immu...
<p>10% (w/v) RML prion-infected brain homogenate was incubated at 37°C with (A) PK (50 µg/ml); (B) t...
We report protease-resistant prion protein (PrPres) in spontaneous lymphoreticular tumors of mice in...
<p><b>(a)</b> Terminal disease lymph node tissue showing granular PrP-d accumulation in Tingible bod...
<p>Groups of four 129/Sv×C57BL/6 and <i>Prnp</i><sup>0/0</sup> mice were inoculated i.p. with 100 µl...
<p>C57BL/6 mice were treated daily for 4 d with RANKL (or PBS as a control) to induce M cell-differe...
<p>After peripheral exposure, prions colonize and replicate in secondary lymphoid organs (SLOs) like...
<p>IHC was performed on A/B) NALT, C) MLN, D) SLN, E) PP and F) SP with the anti-PrP antibody 3F4 (B...
Human prion diseases are fatal neurodegenerative disorders associated with an accumulation of PrPSc ...
<p>TNFR1<sup>−/−</sup> mice inoculated i.p. with 6 log LD<sub>50</sub> RML6 and treated weekly with ...
International audienceIn peripherally acquired prion diseases, prions move through several tissues o...
The key event in the pathogenesis of the transmissible spongiform encephalopathies is a template-dep...
<p>On the left, the purple and red areas on the schematic coronal brain sections designate regions w...
<p>(A) ScN2a-3-22L cells grown on 12-well plates were cultured in the presence or absence of mAb 44B...
In most prion diseases, infectivity accumulates in lymphoreticular organs early after infection. Def...
<p>MPI = months post-inoculation; CNS = central nervous system; Lymph = lymphoid tissues; IHC = immu...
<p>10% (w/v) RML prion-infected brain homogenate was incubated at 37°C with (A) PK (50 µg/ml); (B) t...
We report protease-resistant prion protein (PrPres) in spontaneous lymphoreticular tumors of mice in...
<p><b>(a)</b> Terminal disease lymph node tissue showing granular PrP-d accumulation in Tingible bod...
<p>Groups of four 129/Sv×C57BL/6 and <i>Prnp</i><sup>0/0</sup> mice were inoculated i.p. with 100 µl...
<p>C57BL/6 mice were treated daily for 4 d with RANKL (or PBS as a control) to induce M cell-differe...
<p>After peripheral exposure, prions colonize and replicate in secondary lymphoid organs (SLOs) like...
<p>IHC was performed on A/B) NALT, C) MLN, D) SLN, E) PP and F) SP with the anti-PrP antibody 3F4 (B...
Human prion diseases are fatal neurodegenerative disorders associated with an accumulation of PrPSc ...
<p>TNFR1<sup>−/−</sup> mice inoculated i.p. with 6 log LD<sub>50</sub> RML6 and treated weekly with ...
International audienceIn peripherally acquired prion diseases, prions move through several tissues o...
The key event in the pathogenesis of the transmissible spongiform encephalopathies is a template-dep...
<p>On the left, the purple and red areas on the schematic coronal brain sections designate regions w...
<p>(A) ScN2a-3-22L cells grown on 12-well plates were cultured in the presence or absence of mAb 44B...
In most prion diseases, infectivity accumulates in lymphoreticular organs early after infection. Def...
<p>MPI = months post-inoculation; CNS = central nervous system; Lymph = lymphoid tissues; IHC = immu...
<p>10% (w/v) RML prion-infected brain homogenate was incubated at 37°C with (A) PK (50 µg/ml); (B) t...
We report protease-resistant prion protein (PrPres) in spontaneous lymphoreticular tumors of mice in...