PrP-d accumulation in viscera of CD-1 mice i.p. challenged with rec-Prions.

<p><b>(a)</b> Terminal disease lymph node tissue showing granular PrP-d accumulation in Tingible body macrophages (TBMS, arrowheads) and diffuse punctuate PrP-d accumulation in association with follicular dendritic cells (arrow). Bar = 50μm. <b>(b)</b> Immunogold electron microscopy of terminal disease lymph node shows PrP-d (black) in lysosomes and endo-lysosomes of TBMs. The 1A8 antibody was used for immunogold staining. Bar = 500 nm. <b>(c)</b> Terminal disease intestine showing granular PrP-d accumulation in neurons of enteric nerve plexuses. Bar = 20 μm.