Differential outcome of EAE pathogenesis depending on the SRG3 over-expression pattern in MBP-specific TCR transgenic B10.PL mice: the development of EAE was suppressed in β-actin-SRG3 Tg mice but was facilitated in CD2-SRG3 Tg mice.

<p>(A-B) Both MBP TCR Tg B10.PL mice and CD2-SRG3/MBP TCR double Tg B10.PL mice (upper panel) or both MBP TCR Tg B10.PL mice and β-acin-SRG3/MBP TCR double Tg B10.PL mice (lower panel) were either non-immunized or s.c. immunized with the MBP-Ac1-11 peptide in CFA. (A) Subsequently, the disease severity was monitored daily according to the classical EAE scoring system after immunization; one representative result out of two independent experiments is shown as the mean ± SD of 5 mice per group (*P<0.05, **P<0.01). (B) Spleens were prepared from the aforementioned four experimental groups, and corresponding photographs were captured (upper panel). Additionally, spleen weight (the middle panel) and total cell number (the lower panel) are shown as the mean values ± SD (n = 5; *P<0.05, **P<0.01).