<p>Mice were pre-treated with individual or combined anti-TLR2 or anti-TLR4 antibodies (45 minutes before the CLP procedure). Single treatment resulted in lower levels of TNF-α (A), IL-1β (B), CXCL1 (C) and myeloperoxidase in the lung 6 hours after sepsis compared to the negative control isotype IgG antibody treatment (black bar). The combined treatment with both anti-TLR2 and anti-TLR4 showed moderate improvement when compared to the control treatment-group. * p<0.05 between the CLP and Sham groups. # p<0.05 between the antibody treatment groups and negative control isotype IgG treated-group. Antibody dose (1 mg/animal). Used 6 animals/group, except isotype IgG antibody treated group (n = 10).</p
<p>WT or TLR4<sup>lps-d</sup>/TLR9<sup>−/−</sup> mice were challenged with 8×10<sup>2</sup> CFU <i>K...
<p>Mice were challenged with influenza 1 day after a single inhaled treatment with the described tre...
<p>Serum (A) IL-6, (B) CXCL1, (C) TNF-α, (D) IL-1β, (E) IL-10, and (F) lung MPO activity, and (G) se...
<p>Mice were pre-treated with individual or combined anti-TLR2 or anti-TLR4 antibodies (45 minutes b...
<p>Analysis of parameters of mice pre-treated (45 minutes before the CLP procedure) with individual ...
Introduction. Since the NF-κB pathway regulates both inflammation and host defense, it is uncertain ...
<p>Reverse transcription and real-time PCR assays were performed to quantify steady-state mRNA level...
As part of the innate immune system, Toll-like receptors (TLRs) react rapidly on a pathogen challeng...
<p>Comparison of survival curves between anti-IL-6 antibody-treated mice (n = 9) and control IgG-tre...
Toll-like receptor 4 (TLR4), the signal-transducing molecule of the LPS receptor complex, plays a fu...
<p>CLP was induced in mice (n = 8 in each group), there were three groups: 1- only CLP (white); 2- 3...
Sepsis and septic shock, caused by an excessive systemic host-inflammatory response, are associated ...
(B) The survival rates of WT mice receiving WT or TLR9 DCs were monitored for 6 d after CLP (23 mice...
<p>Mice were challenged with influenza A following a single aerosolized treatment with Pam2-ODN 3 d ...
<p><b>a)</b> Lung tissue sections are stained with hematoxylin and eosin. Images (x40) from lung sec...
<p>WT or TLR4<sup>lps-d</sup>/TLR9<sup>−/−</sup> mice were challenged with 8×10<sup>2</sup> CFU <i>K...
<p>Mice were challenged with influenza 1 day after a single inhaled treatment with the described tre...
<p>Serum (A) IL-6, (B) CXCL1, (C) TNF-α, (D) IL-1β, (E) IL-10, and (F) lung MPO activity, and (G) se...
<p>Mice were pre-treated with individual or combined anti-TLR2 or anti-TLR4 antibodies (45 minutes b...
<p>Analysis of parameters of mice pre-treated (45 minutes before the CLP procedure) with individual ...
Introduction. Since the NF-κB pathway regulates both inflammation and host defense, it is uncertain ...
<p>Reverse transcription and real-time PCR assays were performed to quantify steady-state mRNA level...
As part of the innate immune system, Toll-like receptors (TLRs) react rapidly on a pathogen challeng...
<p>Comparison of survival curves between anti-IL-6 antibody-treated mice (n = 9) and control IgG-tre...
Toll-like receptor 4 (TLR4), the signal-transducing molecule of the LPS receptor complex, plays a fu...
<p>CLP was induced in mice (n = 8 in each group), there were three groups: 1- only CLP (white); 2- 3...
Sepsis and septic shock, caused by an excessive systemic host-inflammatory response, are associated ...
(B) The survival rates of WT mice receiving WT or TLR9 DCs were monitored for 6 d after CLP (23 mice...
<p>Mice were challenged with influenza A following a single aerosolized treatment with Pam2-ODN 3 d ...
<p><b>a)</b> Lung tissue sections are stained with hematoxylin and eosin. Images (x40) from lung sec...
<p>WT or TLR4<sup>lps-d</sup>/TLR9<sup>−/−</sup> mice were challenged with 8×10<sup>2</sup> CFU <i>K...
<p>Mice were challenged with influenza 1 day after a single inhaled treatment with the described tre...
<p>Serum (A) IL-6, (B) CXCL1, (C) TNF-α, (D) IL-1β, (E) IL-10, and (F) lung MPO activity, and (G) se...