Exon number as a predictor of increased gene abundance.

<p>(A) In telencephalon, the number of exons in a gene was a significant predictor of the increase in the expression level of a gene. The inset shows that the ln (delta FPKM) decreases as the ln (Exon number) increases. (B) In ventricle alone and (C) when values from both tissue are pooled (treatment effect), ln (Exon number) is no longer a predictor of the ln (delta FPKM). Note: although sequence length is the independent variable, it is shown on the x-axis to be consistent with reference [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0131669#pone.0131669.ref033" target="_blank">33</a>]. The regression analyses (see inset in A, not shown for B and C) were conducted with ln (Exon number) as the independent variable. All significantly upregulated genes were included, regardless of fold-change.