CD phenotype stratified by the IVS4+10 A>C variant (rs72796353).

<p>Group (1), 43 CD patients heterozygous for the C allele of the rs72796353 variant and no further main <i>NOD2</i> mutant, and 2 patients homozygous for the C allele of the rs72796353 variant; group (2), CD patients without the IVS4+10 A>C variant and with no further main <i>NOD2</i> mutant (<i>NOD2</i> wild-type). ORs are based on the NOD2 wild-type group (e.g., NOD2 wild-type status is protective against perianal fistulas).</p><p>¹ Disease behaviour was defined according to the Montreal classification. A stricturing disease phenotype was defined as presence of stenosis without penetrating disease. The diagnosis of stenosis was made surgically, endoscopically, or radiologically (using MR enteroclysis).</p><p>² Immunosuppressive agents included azathioprine, 6-mercaptopurine, methotrexate, infliximab, and/or adalimumab.</p><p>³ Only surgery related to CD-specific problems (e.g., ileocecal resection, fistulectomy, colectomy, ileostomy) was included.</p><p>CD phenotype stratified by the IVS4+10 A>C variant (rs72796353).