<p>ARR = first dose with Ad35.CS, and the second and third doses with RTS,S/AS01<sub>B</sub></p><p>RRR = three doses with RTS,S/AS01<sub>B</sub></p><p>P values calculated using log-transformed cell frequency per million PBMC in Students t-test</p><p>NP = non-protected; P = protected</p><p>Frequency of CS-specific CD4+ T cells expressing at least 2 cytokines/activation markers per million PBMC, by treatment group and protection status (ATP cohort for immunogenicity).</p
<p>PBMCs isolated from vaccinated animals 7½ weeks after first immunization were stimulated with vac...
Pharmacodynamic biomarkers can play an important role in understanding whether a therapeutic agent h...
<p>Percent of CD4<sup>+</sup> and CD8<sup>+</sup> PBMCs at day 63 producing 1–4 cytokines following ...
<p>ARR = first dose with Ad35.CS, and the second and third doses with RTS,S/AS01<sub>B</sub></p><p>R...
<p>A. Geometric mean CS-specific CD4<sup>+</sup> T cells producing IFN-γ by ELISpot. Comparisons bet...
<p>Seroconversors (Sc+), Non-seroconversors (Sc−).</p><p>*p-value <0.05 comparing Sc- versus Sc+</p>...
The level of activation and proliferation marker expression on CD4+ T cells from unstimulated PBMC s...
BACKGROUND: Knowledge of antigen-specific CD4(+) T cells frequencies is pivotal to the choice of the...
<div><h3>Background</h3><p>Knowledge of antigen-specific CD4<sup>+</sup> T cells frequencies is pivo...
<p>(A) Allogeneic Th1 and Th2 cell lines from three subjects were stimulated with PMA + ionomycin fo...
<p>PBMC were obtained at the indicated time points from RTS,S-immunized subjects and were incubated ...
<p>PBMCs were stimulated with anti-CD3 for 18 h or media alone. Cells were surface stained with anti...
<p><b>A</b>) Ratio of NKG2A+ cells in CD3+CD8+ T cells, <b>B</b>) Ratio of NKG2A+ cells in CD3+CD56+...
<p>(<b>A–B</b>) The frequency of activated CD38+HLA-DR+ T cells in VNPs and PPs by flow cytometry: (...
<p>PBMCs from an RTS,S-immunized volunteer were stimulated in vitro for 18 h with anti-CD28 and anti...
<p>PBMCs isolated from vaccinated animals 7½ weeks after first immunization were stimulated with vac...
Pharmacodynamic biomarkers can play an important role in understanding whether a therapeutic agent h...
<p>Percent of CD4<sup>+</sup> and CD8<sup>+</sup> PBMCs at day 63 producing 1–4 cytokines following ...
<p>ARR = first dose with Ad35.CS, and the second and third doses with RTS,S/AS01<sub>B</sub></p><p>R...
<p>A. Geometric mean CS-specific CD4<sup>+</sup> T cells producing IFN-γ by ELISpot. Comparisons bet...
<p>Seroconversors (Sc+), Non-seroconversors (Sc−).</p><p>*p-value <0.05 comparing Sc- versus Sc+</p>...
The level of activation and proliferation marker expression on CD4+ T cells from unstimulated PBMC s...
BACKGROUND: Knowledge of antigen-specific CD4(+) T cells frequencies is pivotal to the choice of the...
<div><h3>Background</h3><p>Knowledge of antigen-specific CD4<sup>+</sup> T cells frequencies is pivo...
<p>(A) Allogeneic Th1 and Th2 cell lines from three subjects were stimulated with PMA + ionomycin fo...
<p>PBMC were obtained at the indicated time points from RTS,S-immunized subjects and were incubated ...
<p>PBMCs were stimulated with anti-CD3 for 18 h or media alone. Cells were surface stained with anti...
<p><b>A</b>) Ratio of NKG2A+ cells in CD3+CD8+ T cells, <b>B</b>) Ratio of NKG2A+ cells in CD3+CD56+...
<p>(<b>A–B</b>) The frequency of activated CD38+HLA-DR+ T cells in VNPs and PPs by flow cytometry: (...
<p>PBMCs from an RTS,S-immunized volunteer were stimulated in vitro for 18 h with anti-CD28 and anti...
<p>PBMCs isolated from vaccinated animals 7½ weeks after first immunization were stimulated with vac...
Pharmacodynamic biomarkers can play an important role in understanding whether a therapeutic agent h...
<p>Percent of CD4<sup>+</sup> and CD8<sup>+</sup> PBMCs at day 63 producing 1–4 cytokines following ...