Blockade of IL-12 and IFNγ during co-infection preserves Th2 responses.

<p>A-C). C57BL/6 mice were orally infected with 200 <i>H</i>. <i>polygyrus</i> larvae. 6 days post-infection, mice were infected with 10⁵<i>P</i>. <i>chabaudi</i>. At day 8-post infection with <i>P</i>. <i>chabaudi</i> (d14 <i>H</i>. <i>polygyrus</i>), mice were harvested. Mice were treated with 0.5 mg of anti-IL-12 and anti-IFNγ i.p. at days 0, 5, and 11. B). Total numbers of CD4⁺CD44^hi<i>Il4</i>^gfp+ cells in the mesenteric lymph nodes. C). IgE measured in the serum by ELISA. Data are representative of 2 independent experiments with 6 mice per group. * denotes P<0.05.