Overview of the conservation calculation method.

<p>(A) Schematic explanation of the comparison method for the conserved gene lists. Prepare a gene list pair for an orthologous gene pair from human and mouse. Count the number of human genes (yellow highlighted genes) with corresponding genes in the top <i>N</i> genes, where green arrows mean corresponding gene pairs. When a human gene corresponds to multiple mouse genes, we counted one human gene. However, when a mouse gene corresponds to multiple human genes, we counted all of the human genes. (B) Conservation chart of (A). This chart illustrates the change in the number of corresponding genes against the parameter value, <i>N</i>. (C) An example of a conservation chart for the most conserved guide gene. (D) An example of a conservation chart with a typical shape. (E) An example of genes with a turning point.