Novel Chalcone–Thiazole Hybrids as Potent Inhibitors of Drug Resistant <i>Staphylococcus aureus</i>

A series of novel hybrids possessing chalcone and thiazole moieties were synthesized and evaluated for their antibacterial activities. In general this class of hybrids exhibited potency against <i>Staphylococcus aureus</i>, and in particular, compound <b>27</b> exhibited potent inhibitory activity with respect to other synthesized hybrids. Furthermore, the hemolytic and toxicity data demonstrated that the compound <b>27</b> was nonhemolytic and nontoxic to mammalian cells. The <i>in vivo</i> studies utilizing a <i>S. aureus</i> septicemia model demonstrated that compound <b>27</b> was as potent as vancomycin. The results of antibacterial activities underscore the potential of this scaffold that can be utilized for developing a new class of novel antibiotics