Metabolic effect and oral glucose test after anti-IL20 treatment.

<p>One week post last treatment with anti-IL-20, the mice was terminated. During the experiment and at time of termination HbA1c (A), blood glucose (B) and weight (C) was determined. Oral glucose evaluation was conducted one day before termination of the experiment (D). Area under the curve oral glucose test was calculated (E). Plasma level of insulin was measured during the oral glucose tolerance test (F). Each group contained 12 animals. Statistical evaluation comparing the start value in each group with the termination value as well as the termination value between the groups was performed with one way ANOVA in A-C. Linear regression analysis was performed to determine if the two groups showed a difference in the slope of the parameter evaluated during the time of the experiment A-C. Student’s T-test was used to determine statistical significance in E.