Batten disease affected sheep body weight changes and <i>post mortem</i> brain appearance.

<p>(A) Mean (± SEM) body weight of control (blue) and Batten disease affected sheep (red) from birth to 20 months of age shows that growth of Batten disease affected animals stopped at around 14 months. The dotted line indicates the time of transfer from the home farm to the MRI facility. (B) Comparison of gross anatomy of brains from a control sheep (left) and the least affected wether (male, 939), and least affected ewe (female, 937) (centre and right respectively) shows pronounced atrophy of the cerebral cortex (Co) with relative sparing of the cerebellum (Cb). Brains were fixed with 4% paraformaldehyde. Size bar in B represents 3cm.