<div><p>The neuroendocrine peptides CCHamide-1 and -2, encoded by the genes <i>ccha1</i> and <i>-2</i>, are produced by endocrine cells in the midgut and by neurons in the brain of <i>Drosophila melanogaster</i>. Here, we used the CRISPR/Cas9 technique to disrupt the <i>ccha1</i> and <i>-2</i> genes and identify mutant phenotypes with a focus on <i>ccha-2</i> mutants. We found that both larval and adult <i>ccha2</i> mutants showed a significantly reduced food intake as measured in adult flies by the Capillary Feeding (CAFE) assay (up to 72% reduced food intake compared to wild-type). Locomotion tests in adult flies showed that <i>ccha2</i> mutants had a significantly reduced locomotor activity especially around 8 a.m. and 8 p.m., where adul...
Complexity in multi-cellular life arises from the ability of tissues to communicate with each other;...
Summary: Lipid droplets (LDs) are the universal cellular storage organelles for esterified neutral l...
Fruit flies have eight identified Drosophila insulin-like peptides (DILPs) that are involved in the ...
The neuroendocrine peptides CCHamide-1 and -2, encoded by the genes ccha1 and -2, are produced by en...
The neuroendocrine peptides CCHamide-1 and-2, encoded by the genes ccha1 and-2, are produced by endo...
<div><p>The insect neuropeptides CCHamide-1 and -2 are recently discovered peptides that probably oc...
The insect neuropeptides CCHamide-1 and-2 are recently discovered peptides that probably occur in al...
The insect neuropeptides CCHamide-1 and -2 are recently discovered peptides that probably occur in a...
<div><p>The coordination of growth with nutritional status is essential for proper development and p...
Neuropeptides are processed from larger preproproteins by a dedicated set of enzymes. The molecular ...
AbstractBackground: The insulin/IGF-1 signaling pathway controls cellular and organismal growth in m...
The intake of macronutrients is crucial for the fitness of any animal and is mainly regulated by per...
Regulatory peptides, which comprise neuropeptides and peptide hormones, are cell-cell signaling mole...
There are many orphan G-protein-coupled receptors (GPCRs) for which ligands have not yet been identi...
The coordination of growth with nutritional status is essential for proper development and physiolog...
Complexity in multi-cellular life arises from the ability of tissues to communicate with each other;...
Summary: Lipid droplets (LDs) are the universal cellular storage organelles for esterified neutral l...
Fruit flies have eight identified Drosophila insulin-like peptides (DILPs) that are involved in the ...
The neuroendocrine peptides CCHamide-1 and -2, encoded by the genes ccha1 and -2, are produced by en...
The neuroendocrine peptides CCHamide-1 and-2, encoded by the genes ccha1 and-2, are produced by endo...
<div><p>The insect neuropeptides CCHamide-1 and -2 are recently discovered peptides that probably oc...
The insect neuropeptides CCHamide-1 and-2 are recently discovered peptides that probably occur in al...
The insect neuropeptides CCHamide-1 and -2 are recently discovered peptides that probably occur in a...
<div><p>The coordination of growth with nutritional status is essential for proper development and p...
Neuropeptides are processed from larger preproproteins by a dedicated set of enzymes. The molecular ...
AbstractBackground: The insulin/IGF-1 signaling pathway controls cellular and organismal growth in m...
The intake of macronutrients is crucial for the fitness of any animal and is mainly regulated by per...
Regulatory peptides, which comprise neuropeptides and peptide hormones, are cell-cell signaling mole...
There are many orphan G-protein-coupled receptors (GPCRs) for which ligands have not yet been identi...
The coordination of growth with nutritional status is essential for proper development and physiolog...
Complexity in multi-cellular life arises from the ability of tissues to communicate with each other;...
Summary: Lipid droplets (LDs) are the universal cellular storage organelles for esterified neutral l...
Fruit flies have eight identified Drosophila insulin-like peptides (DILPs) that are involved in the ...