Dual FXR/TGR5 agonist BAR502 improves liver injury in both GPBAR1<sup>+/+</sup> and GPBAR1<sup>-/-</sup> mice.
- Sabrina Cipriani (134132)
- Barbara Renga (134135)
- Claudio D’Amore (770255)
- Michele Simonetti (770256)
- Antonio Angelo De Tursi (770257)
- Adriana Carino (277117)
- Maria Chiara Monti (186804)
- Valentina Sepe (186788)
- Angela Zampella (186821)
- Stefano Fiorucci (134151)
DOIAbstract
<p>GPBAR1<sup><b>+/+</b></sup> and GPBAR1<sup><b>-/-</b></sup> mice were treated for 10 days with ANIT or with the combination of ANIT plus BAR502. Serum levels of (A) bilirubin, (B) Alkaline phosphatase and (C) AST. Results are the mean ± SE of 4–8 mice per group. *p<0.05 versus GPBAR<sup><b>+/+</b></sup> mice. °p<0.05 versus GPBAR1<sup><b>+/+</b></sup> mice treated with ANIT. **p<0.05 versus GPBAR1<sup><b>-/-</b></sup> mice. #p<0.05 versus GP-BAR<sup><b>-/-</b></sup> mice administered with ANIT. (D) Representative histological pictures of H&E-stained livers. (E) Analysis of the number of lesions per field. Results are the mean ± SE of 4–8 mice per group. *p<0.05 versus GPBAR1<sup><b>+/+</b></sup> mice. °p<0.05 versus GPBAR1<sup><b>+/+</b>...
Add to ORKG