Effects of Liraglutide treatment on the bone micro-architecture of the femur in OVX rats.

<p>(A) Representative micro-CT images of the right femur. (B) The trabecular micro-architecture parameters of the distal end of the femur were shown as: BV/TV, Tb.Th, Tb.N, Tb.Sp, and trabecular BMD. The cortical parameters were also exhibited as the cortical BMD and cortical wall thickness. Eight-week-old female Wistar rats were subjected to a sham ovariectomy (SHAM, black bar) or ovariectomy surgery (OVX); then, 3 months after surgery when the rats had established osteoporosis, vehicle (OVX, white bar) or Liraglutide (OVX+L, red bar) were administered for 8 weeks. Values are expressed as the mean±SE; n = 6 rats per group.*, P<0.05; **, P<0.01; ***, P<0.001.