Effects of Liraglutide on the bone micro-architecture of the vertebra in OVX rats.

<p>(A) Representative micro-CT images of the 5th lumbar vertebra. The upper row presents the coronal view, axial view and sagittal view in the different groups, while the lower row provides a three-dimensional visualization of the trabecular micro-architecture. (B) The trabecular micro-architecture parameters of the 5th lumbar vertebra were shown as: BV/TV, Tb.Th, Tb.N, trabecular BMD, and Tb.Sp. Eight-week-old female Wistar rats were subjected to a sham ovariectomy (SHAM, black bar) or ovariectomy surgery (OVX); then, 3 months after surgery when the rats had established osteoporosis, vehicle (OVX, white bar) or Liraglutide (OVX+L, red bar) were administered for 8 weeks. Values are expressed as the mean±SE; n = 6 rats per group. *, P< 0.05; **, P< 0.01, ***, P<0.001.