<p>(a) PC-9 cells were treated with rapamycin for 24 h, and then cell lysates were assayed for p-AKT by Western blotting. (b) PC-9 cells were treated with rapamycin for 24 h and GSK690693 for 1 h respectively, or pre-treated with 10 μM GSK690693 for 1 h and then with rapamycin for 24 h. The cells were probed for p-AKT. (c) Glucose uptake was assayed in PC-9 cells treated with GSK690693, rapamycin, or in the combination. The experiments were repeated for at least three times. Data represent mean ± SD, ***<i>P</i> < 0.001.</p
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that plays an important role i...
<p>ECC-1 cell line (<b>A</b>) and EC6-Ep primary epithelial cell (<b>B</b>) were treated with increa...
<p>BHK-ABCA1 cells were induced overnight with mifepristone (10 nM) and then incubated with DEBC, LY...
<p>Akt phosphorylation at sites Thr308 (A) and Ser473 (B) in primary RGCs was determined by western ...
Deregulation of the phosphoinositide 3-kinase-Akt pathway is a major contributor to oncogenesis and ...
<p>(a) A549 cells were treated with AZD2014 and rapamycin. (b) PC-9 cells were treated with AZD2014 ...
Cancer metabolism has greatly interested researchers. Mammalian target of rapamycin (mTOR) is dysreg...
<div><p>Cancer metabolism has greatly interested researchers. Mammalian target of rapamycin (mTOR) i...
Although poorly understood, normal cells and cancerous cells of the same type exhibit different patt...
<p>(A–C) Rapamycin decreased the phosphorylation of the mTORC1 downstream target p70S6K in podocytes...
<p><b>(A)</b> Cells were treated with MK2206 (A549: 5 μM; H460: 2.5 μM) for 1 h, followed by treatme...
<p>(A) VHL protein levels, as well as the activity of Akt/mTOR and its downstream targets measured b...
<p>(A), representative immunostaining for p-Akt, p-S6, and Ki67 in vehicle- and rapamycin-treated gr...
The mTOR pathway is a master regulator of cellular growth and metabolism. The biosynthetic and energ...
<p>A549 cells were treated with vehicle control (0.1% DMSO), Dasatinib (10 nM) with or without Rapam...
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that plays an important role i...
<p>ECC-1 cell line (<b>A</b>) and EC6-Ep primary epithelial cell (<b>B</b>) were treated with increa...
<p>BHK-ABCA1 cells were induced overnight with mifepristone (10 nM) and then incubated with DEBC, LY...
<p>Akt phosphorylation at sites Thr308 (A) and Ser473 (B) in primary RGCs was determined by western ...
Deregulation of the phosphoinositide 3-kinase-Akt pathway is a major contributor to oncogenesis and ...
<p>(a) A549 cells were treated with AZD2014 and rapamycin. (b) PC-9 cells were treated with AZD2014 ...
Cancer metabolism has greatly interested researchers. Mammalian target of rapamycin (mTOR) is dysreg...
<div><p>Cancer metabolism has greatly interested researchers. Mammalian target of rapamycin (mTOR) i...
Although poorly understood, normal cells and cancerous cells of the same type exhibit different patt...
<p>(A–C) Rapamycin decreased the phosphorylation of the mTORC1 downstream target p70S6K in podocytes...
<p><b>(A)</b> Cells were treated with MK2206 (A549: 5 μM; H460: 2.5 μM) for 1 h, followed by treatme...
<p>(A) VHL protein levels, as well as the activity of Akt/mTOR and its downstream targets measured b...
<p>(A), representative immunostaining for p-Akt, p-S6, and Ki67 in vehicle- and rapamycin-treated gr...
The mTOR pathway is a master regulator of cellular growth and metabolism. The biosynthetic and energ...
<p>A549 cells were treated with vehicle control (0.1% DMSO), Dasatinib (10 nM) with or without Rapam...
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that plays an important role i...
<p>ECC-1 cell line (<b>A</b>) and EC6-Ep primary epithelial cell (<b>B</b>) were treated with increa...
<p>BHK-ABCA1 cells were induced overnight with mifepristone (10 nM) and then incubated with DEBC, LY...