Quality of studies using QUADAS tool.

<p>QUADAS, Quality Assessment of Diagnostic Accuracy Studies; Y, yes; N, no; U, unclear. Item 1. Was the spectrum of patients representative of the patients who will receive the test in practice? Item 2. Were selection criteria clearly described? Item 3. Is the reference standard likely to correctly classify the target condition? Item 4. Is the time period between reference standard and index test short enough to be reasonably sure that the target condition did not change between the two tests? Item 5. Did the whole sample or a random selection of the sample receive verification by using a reference standard of diagnosis? Item 6. Did patients receive the same reference standard regardless of the index test result? Item 7. Was the reference standard independent of the index test? Item 8. Was the execution of the index test described in sufficient detail to permit replication of the test? Item 9. Was the execution of the reference standard described in sufficient detail to permit its replication? Item 10. Were the index test results interpreted without knowledge of the results of the reference standard? Item 11. Were the reference standard results interpreted without knowledge of the results of the index test? Item 12. Were the same clinical data available when test results were interpreted as would be available when the test is used in practice? Item 13. Were uninterpretable/intermediate test results reported? Item 14. Were withdrawals from the study explained?</p><p>Quality of studies using QUADAS tool.