Palladium(II)-Catalyzed C–H Bond Activation/C–C Coupling/Intramolecular Tsuji–Trost Reaction Cascade: Facile Access to 2<i>H</i>‑Pyrano­naphtho­quinones

An efficient one-pot synthesis of 2<i>H</i>-pyrano­naphtho­quinone was achieved via a palladium-catalyzed C–H bond activation/C–C bond formation/intramolecular Tsuji–Trost reaction cascade. The unprecedented procedure exhibits excellent functional group tolerance, giving the target naphthoquinones in moderate to good isolated yields (40–88%) under mild reaction conditions. Scalable production of the product can make this reaction a method of choice for the synthesis of 2<i>H</i>-pyrano­naphtho­quinones