<p>IDE<sub>C</sub> and IDE<sub>O</sub> represent the closed and open conformations of IDE respectfully. A is a peptide substrate while P and Q are the peptide products derived from the cleavage of A.</p
<p>Kinetic constants were determined by measuring rates at variable concentration of Abz-GGFLRKHGQ-E...
<p>Panels A and B show the cleavage of two substrates, one containing Phe in the P1 position and one...
Selectivity and efficiency of enzymes can be fruitfully exploited in peptide chemistry for amide bon...
<p>(A) The kinetic scheme for the interaction of substrate with a two-state handle region, where the...
<p>(a) Model substrate (b) <i>C</i>-terminal-anchored peptides (c) <i>N</i>-terminal-anchored peptid...
Since the introduction of kinetically controlled ligation (KCL), a chemoselective reaction between a...
International audienceInsulin-degrading enzyme (IDE) is a ubiquitously expressed metallopeptidase th...
The chemical step of protein synthesis, peptide bond formation, is catalyzed by the large subunit of...
Abstract- Novel synthetic strategies based on the chemical models designed to simulate the enzyme ac...
<p>Kinetic mechanism of Nei processing of the DHU/C<sup>py</sup>- and DHU/tC<sup>O</sup>-substrates....
Insulin degrading enzyme (IDE) is a key enzyme in the metabolism of both insulin and amyloid beta pe...
<p>a) activity against E. Coli. b) activity against red blood cells. The lines correspond to the the...
<p>The kinetic scheme describing the interactions of APE1K98A with specific DHU-substrate during NIR...
<p>(a) Time course (0.5-60 minutes) of the cleavage reaction of the purified hTop1 (lanes 1-8), or h...
An important question in Systems Biology is the design of experiments to allow discrimination betwee...
<p>Kinetic constants were determined by measuring rates at variable concentration of Abz-GGFLRKHGQ-E...
<p>Panels A and B show the cleavage of two substrates, one containing Phe in the P1 position and one...
Selectivity and efficiency of enzymes can be fruitfully exploited in peptide chemistry for amide bon...
<p>(A) The kinetic scheme for the interaction of substrate with a two-state handle region, where the...
<p>(a) Model substrate (b) <i>C</i>-terminal-anchored peptides (c) <i>N</i>-terminal-anchored peptid...
Since the introduction of kinetically controlled ligation (KCL), a chemoselective reaction between a...
International audienceInsulin-degrading enzyme (IDE) is a ubiquitously expressed metallopeptidase th...
The chemical step of protein synthesis, peptide bond formation, is catalyzed by the large subunit of...
Abstract- Novel synthetic strategies based on the chemical models designed to simulate the enzyme ac...
<p>Kinetic mechanism of Nei processing of the DHU/C<sup>py</sup>- and DHU/tC<sup>O</sup>-substrates....
Insulin degrading enzyme (IDE) is a key enzyme in the metabolism of both insulin and amyloid beta pe...
<p>a) activity against E. Coli. b) activity against red blood cells. The lines correspond to the the...
<p>The kinetic scheme describing the interactions of APE1K98A with specific DHU-substrate during NIR...
<p>(a) Time course (0.5-60 minutes) of the cleavage reaction of the purified hTop1 (lanes 1-8), or h...
An important question in Systems Biology is the design of experiments to allow discrimination betwee...
<p>Kinetic constants were determined by measuring rates at variable concentration of Abz-GGFLRKHGQ-E...
<p>Panels A and B show the cleavage of two substrates, one containing Phe in the P1 position and one...
Selectivity and efficiency of enzymes can be fruitfully exploited in peptide chemistry for amide bon...
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