TT-specific CD4+CD154+ CD3+ responses over time following HibMenCY-TT vaccine.

<p>The frequency above background (Δ) of TT-specific CD4+CD154+ memory cells in CD3+ lymphocytes was determined in PBMCs from infants after 2 doses (M6) or 3 doses (M7) of prime, prior to (M12), and 1 month post (M13) a booster dose of HibMenCY-TT. Each point represents the response from 1 individual and the horizontal bars represent median values. Red dots represent paired samples from individuals who had blood taken following 2 doses of HibMenCY-TT prime, whilst black dots represent those samples from individuals who had blood taken after 3 doses of HibMenCY-TT prime. p(*)≤0.05, indicating significance of related samples Wilcoxon signed rank tests.