Exercise training did not reduce nerve injury-induced muscle wasting.

<p><b>(A)</b> The inverted screen test of muscle strength was performed on mice 3 weeks (POD 21/22) after injury with a cut off latency of 120 sec (dotted line). SNI mice had a shorter latency to fall than uninjured mice in Trial 2 only (p = 0.0002). Despite exercise training for 12 hr/night for 9 nights, latency to fall of SNI, exercise mice was not improved compared to SNI, control mice, n = 6–8. <b>(B)</b> By POD 25 SNI gave rise to a robust reduction in ipsilateral gastrocnemius muscle wet weight (p<0.0001), which was unchanged by exercise, n = 6–8. Compared to uninjured controls, gastrocnemius muscle wet weight of uninjured, exercise mice was significantly reduced in the ipsilateral (p<0.01), but not the contralateral hindlimb. Data are presented as mean ± SEM. **p<0.01, ***p<0.001, ****p<0.0001, One-way ANOVA, Bonferroni correction for multiple comparisons.