<p>A) HPLC trace DMF (elution time 3.31 min) and phosphate buffer (elution time 2.48 min). B) Trace for Melatonin (3.98 min) dissolved in DMF. C) Addition of MPO causes no significant change in melatonin peak intensity and/or retention time. D) Addition of exogenous H<sub>2</sub>O<sub>2</sub> (sequential addition of 20 μM, total 200 μM) results in a significant shift in melatonin retention time elution time to a hydroxylated intermediate (3.71 min). E) Incubation of MPO and melatonin in the presence of oocytes produces similar peaks and retention time to exogenously added H<sub>2</sub>O<sub>2</sub>, signifying that H<sub>2</sub>O<sub>2</sub> released from the oocytes reacts with MPO causing melatonin oxidation.</p
Melatonin is catabolized both enzymatically and nonenzymatically. Nonenzymatic processes mediated by...
The indolamine melatonin (MEL) is described as an antioxidant and a free radical scavenger. However ...
Melatonin is a tryptophan-derived molecule with pleiotropic activities. It is present in almost all ...
<p>Fixed amount of MPO (1 μM) was incubated with fixed amount of Cl<sup>-</sup> (100 mM) and increas...
Melatonin is an efficient protector against hydrogen peroxide(H2O2)-induced lipid peroxidation and a...
<p>(A, B) In both 143B cells and NARP cybrids, ΔΨm depolarization was faster in the group with H<sub...
Melatonin is a potent scavenger of reactive oxygen species or free radicals like superoxide...
The possible role of melatonin in melanogenesis was investigated by performing reactions of melatoni...
Intracellular Pro-oxidant Activity of Melatonin Deprives U937 Cells of Reduced Glutathione without A...
Objective We evaluated the effect of melatonin, as a potent antioxidant agent, on glutathione (GSH)...
This review summarizes some of the recent findings concerning the long-held tenet that the enzyme, N...
<p>MPO (1.2 μM) was incubated with 100 mM Cl<sup>−</sup> in the absence and presence of 400 μM MLT f...
The physiology of oocyte in vitro maturation remains elusive. Generally, the oocytes have a very low...
Carbon-centred free radicals can be involved in damage to biological systems under hypoxic/anoxic co...
Myeloperoxidase uses hydrogen peroxide to oxidize numerous substrates to hypohalous acids or reactiv...
Melatonin is catabolized both enzymatically and nonenzymatically. Nonenzymatic processes mediated by...
The indolamine melatonin (MEL) is described as an antioxidant and a free radical scavenger. However ...
Melatonin is a tryptophan-derived molecule with pleiotropic activities. It is present in almost all ...
<p>Fixed amount of MPO (1 μM) was incubated with fixed amount of Cl<sup>-</sup> (100 mM) and increas...
Melatonin is an efficient protector against hydrogen peroxide(H2O2)-induced lipid peroxidation and a...
<p>(A, B) In both 143B cells and NARP cybrids, ΔΨm depolarization was faster in the group with H<sub...
Melatonin is a potent scavenger of reactive oxygen species or free radicals like superoxide...
The possible role of melatonin in melanogenesis was investigated by performing reactions of melatoni...
Intracellular Pro-oxidant Activity of Melatonin Deprives U937 Cells of Reduced Glutathione without A...
Objective We evaluated the effect of melatonin, as a potent antioxidant agent, on glutathione (GSH)...
This review summarizes some of the recent findings concerning the long-held tenet that the enzyme, N...
<p>MPO (1.2 μM) was incubated with 100 mM Cl<sup>−</sup> in the absence and presence of 400 μM MLT f...
The physiology of oocyte in vitro maturation remains elusive. Generally, the oocytes have a very low...
Carbon-centred free radicals can be involved in damage to biological systems under hypoxic/anoxic co...
Myeloperoxidase uses hydrogen peroxide to oxidize numerous substrates to hypohalous acids or reactiv...
Melatonin is catabolized both enzymatically and nonenzymatically. Nonenzymatic processes mediated by...
The indolamine melatonin (MEL) is described as an antioxidant and a free radical scavenger. However ...
Melatonin is a tryptophan-derived molecule with pleiotropic activities. It is present in almost all ...