Immune modulation by histamine during <i>L</i>. <i>sigmondontis</i> infection.

<p><i>(A)</i> Total IgE from mice treated with fexofenadine (HR1i) measured by ELISA. <i>(B)</i> Parasite specific (LsAg) IgE in mice treated with fexofenadine (HR1i) measured by ELISA. <i>(C</i>, <i>D</i>, <i>E)</i> IL-4, IL-5 and IFN-γ production by CD4⁺ cells from infected fexofenadine treated mice co-cultured with CD11c⁺ cells from naïve, age-matched mice and activated with anti-CD3/anti-CD28. Cells were cultured 1:10 (CD11c⁺:CD4⁺). Cytokine production was measured by ELISA. Data are from two combined experiments. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001, Kruskal-Wallis test followed by Dunn Multiple comparisons.