Versatile Core–Shell Nanoparticle@Metal–Organic Framework Nanohybrids: Exploiting Mussel-Inspired Polydopamine for Tailored Structural Integration

We report a versatile strategy based on the use of multifunctional mussel-inspired polydopamine for constructing well-defined single-nanoparticle@metal–organic framework (MOF) core–shell nanohybrids. The capability of polydopamine to form a robust conformal coating on colloidal substrates of any composition and to direct the heterogeneous nucleation and growth of MOFs makes it possible for customized structural integration of a broad range of inorganic/organic nanoparticles and functional MOFs. Furthermore, the unique redox activity of polydopamine adds additional possibilities to tailor the functionalities of the nanohybrids by sandwiching plasmonic/catalytic metal nanostructures between the core and shell <i>via</i> localized reduction. The core–shell nanohybrids, with the molecular sieving effect of the MOF shell complementing the intrinsic properties of nanoparticle cores, represent a unique class of nanomaterials of considerable current interest for catalysis, sensing, and nanomedicine