The effect of pregnancy on GABA<sub>A</sub>R δ- and γ2-subunit protein expression in the hippocampus and cerebral cortex.
- Abbie Chapman Johnson (663603)
- Keith J. Nagle (663608)
- Sarah M. Tremble (663604)
- Marilyn J. Cipolla (663609)
Publication date
July 2015
DOIAbstract
<p>(A) Representative Western blots showing protein expression of the GABA<sub>A</sub>R <b>γ</b>2-subunit and δ-subunit in the cerebral cortex of nonpregnant (Nonpreg) and pregnant (Preg) rats. (B) GABA<sub>A</sub>R <b>γ</b>2-subunit protein expression was significantly lower in the hippocampus from Preg compared to Nonpreg rats, and GABA<sub>A</sub>R δ-subunit expression trended towards being decreased in the hippocampus of Preg compared to Nonpreg rats. (C) Cortical GABA<sub>A</sub>R <b>γ</b>2-subunit expression was similar in Preg and Nonpreg rats, however, GABA<sub>A</sub>R δ-subunit expression was decreased in the cerebral cortex of Preg compared to Nonpreg rats. ** p < 0.01; * p < 0.05 vs. Nonpreg using Student’s t-test.</p
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