Changes of lung (A) superoxide production and (B) water accumulation in rats treated with lipopolysaccharide (LPS).

<p>Depicted are changes in superoxide production and water accumulation at the end of experiment (at 6 h) in rats that received saline (Control; 0.9% NaCl, i.v., n = 7) or LPS (10 mg/kg, i.v., n = 7). Data expressed as mean ± SEM. *<i>P</i> < 0.05, LPS vs. Control. <b>(C) Polymorphonuclear neutrophil (PMN) infiltration index and (D) representative histopathologic features of lung tissue sections obtained from rats treated with LPS.</b> Depiction of the changes in PMN infiltration index at the end of experiment (at 6 h) in different groups of animals which received saline (Control, 0.9% NaCl, i.v., n = 3) or LPS (10 mg/kg, i.v., n = 3). Data expressed as mean ± SEM. *P < 0.05, LPS vs. Control. Light microscopy showed lung sections of rats in Control and LPS group. Arrows represent neutrophil infiltration and interstitial edema. Original magnification x 400.