<p>For the two compounds whose pharmacokinetics is described by Eqs <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0133653#pone.0133653.e004" target="_blank">3</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0133653#pone.0133653.e005" target="_blank">4</a>, the table lists the respective PK parameters: partition coefficients <i>κ</i>, permeabilities <i>P</i>, metabolization parameters </p><p></p><p></p><p></p><p><mi>V</mi>maxcell</p><p></p><p></p><p></p> and <p></p><p></p><p></p><p><mi>K</mi><mi>m</mi>cell</p><p></p><p></p><p></p>; the lipophilicity log <i>P</i><p></p
Allometric scaling is widely used to predict human pharmacokinetic parameters from preclinical speci...
Allometric scaling is widely used to predict human pharmacokinetic parameters from preclinical speci...
<p>* The term “compartment” refers to a volume of body fluid into which a drug distributes. Examples...
<p>The table lists the PBPK model parameters for CFDA SE, midazolam, and spiramycin used in our simu...
<p>median parameter and range. see Table 4 for individual values. value set to 1 <a href="http://w...
<p>(*) <i>p</i><0.05 and (**) <i>p</i> <0.01 compared with product C.</p><p>Pharmacokinetic paramete...
<p>The table displays the estimated pharmacokinetic parameter estimates for healthy individuals. Int...
In drug discovery and development, the kinetic study of active metabolites plays an important role, ...
<p>Pharmacokinetic parameter estimates for mice, rats, and dogs obtained by simultaneously fitting o...
<p>Values in parentheses and italics are corresponding human data for biopsy and blood compartments ...
<p>t<sub>lag</sub>, lag time; t<sub>max</sub>, peak concentration time; C<sub>max</sub>, peak concen...
<p>Pharmacokinetic parameters, estimated with the final two-compartment models.</p
OBJECTIVE: One of the problems in the application of physiologically based pharmacokinetic (PB-PK) m...
OBJECTIVE: One of the problems in the application of physiologically based pharmacokinetic (PB-PK) m...
<p>Pharmacokinetic parameters and their variability in the study population (5th - 95th percentile),...
Allometric scaling is widely used to predict human pharmacokinetic parameters from preclinical speci...
Allometric scaling is widely used to predict human pharmacokinetic parameters from preclinical speci...
<p>* The term “compartment” refers to a volume of body fluid into which a drug distributes. Examples...
<p>The table lists the PBPK model parameters for CFDA SE, midazolam, and spiramycin used in our simu...
<p>median parameter and range. see Table 4 for individual values. value set to 1 <a href="http://w...
<p>(*) <i>p</i><0.05 and (**) <i>p</i> <0.01 compared with product C.</p><p>Pharmacokinetic paramete...
<p>The table displays the estimated pharmacokinetic parameter estimates for healthy individuals. Int...
In drug discovery and development, the kinetic study of active metabolites plays an important role, ...
<p>Pharmacokinetic parameter estimates for mice, rats, and dogs obtained by simultaneously fitting o...
<p>Values in parentheses and italics are corresponding human data for biopsy and blood compartments ...
<p>t<sub>lag</sub>, lag time; t<sub>max</sub>, peak concentration time; C<sub>max</sub>, peak concen...
<p>Pharmacokinetic parameters, estimated with the final two-compartment models.</p
OBJECTIVE: One of the problems in the application of physiologically based pharmacokinetic (PB-PK) m...
OBJECTIVE: One of the problems in the application of physiologically based pharmacokinetic (PB-PK) m...
<p>Pharmacokinetic parameters and their variability in the study population (5th - 95th percentile),...
Allometric scaling is widely used to predict human pharmacokinetic parameters from preclinical speci...
Allometric scaling is widely used to predict human pharmacokinetic parameters from preclinical speci...
<p>* The term “compartment” refers to a volume of body fluid into which a drug distributes. Examples...