Glibenclamide quantification after intracranioventricular drug delivery.

<p>(<b>A</b>) Representative photograph of Nissl stained coronal section from a chronically ICV implanted rat (Scale bar: 500μm). (<b>B</b>) Glibenclamide concentrations in plasma (black circles) and CSF (grey circles) of rats given vehicle (n = 4) or glibenclamide (n = 6) by acute ICV injection. (<b>C</b>) CSF-to-plasma glibenclamide concentration ratio of rats given glibenclamide by acute ICV injection. All data are measurements from individual rats.