Effect of P-glycoprotein inhibition on glibenclamide concentrations.

<p>(<b>A</b>) Individual glibenclamide concentrations in plasma of rats injected intraperitoneally with 50mg/kg glibenclamide in the presence of elacridar (n = 11; grey bars) or vehicle (n = 10; black bars). (<b>B</b>) Individual glibenclamide concentrations measured in the CSF and brain homogenate of the rats injected with glibenclamide in the presence of elacridar (grey circles; n = 10 for CSF, n = 6 for brain) or vehicle (black circles; n = 9 for CSF, n = 6 for brain). (<b>C</b>) CSF-to-plasma and brain-to-plasma glibenclamide concentration ratio of rats injected IP with glibenclamide in the presence of elacridar (grey circles) or vehicle (black circles). Data are measurements from individual rats. The mean of each group is represented by the black bar. n.s. not statistically significant [Two-tailed unpaired Student’s t-test].