Clustering of sequenced isolates by genomic similarity.

<p>(<b>A</b>) Network diagram of all 1,229 sequenced isolates that could be assigned to one of 78 clusters on the basis of pairwise ANIb. Each node represents an individual isolate, and is colored black if robustly matching a previously reported genome (≥ 95% ANIb) or white if corresponding to a novel genomospecies. Nodes connected by a visible edge indicate pairwise ANIb values ≥ 95%. Edges connecting isolates within the same cluster are colored according to that cluster, edges connecting isolates that match multiple clusters are grey. Clusters are labeled according to the most detailed taxonomic classification given to isolates during conventional identification. (<b>B</b>) Network diagram of 419 isolates corresponding to novel genomospecies, assigned to 53 clusters on the basis of pairwise ANIb. Clusters are labeled as in (A). For both panels, the length of edges between nodes is not informative or proportional to ANIb values, and consequently neither is the placement of specific nodes or groups within the graph. The amount of connectivity among nodes indicates the basis of their inclusion with respect to specific groups.