Synthesis, Characterization, and Antimicrobial Potential of Some 1,4-Disubstituted 1,2,3-Bistriazoles

<div><p></p><p>A convenient synthesis of some new 1,4-disubstituted 1,2,3-bistriazoles <b>(3a</b>–<b>3f, 4a</b>–<b>4f, 6a–6b, 7a–7b)</b> is reported via copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition of various terminal alkynes with 1,4-bis(azidomethyl)benzene and 1,6-diazidohexane. The synthesized compounds were characterized by spectral techniques including infrared, ¹H NMR, ¹³C NMR, and high-resolution mass spectrometry and tested in vitro for antimicrobial potential against <i>Bacillus subtilis</i> and <i>Staphylococcus aureus</i> (Gram-positive bacteria), <i>Pseudomonas aeruginosa</i> and <i>Escherichia coli</i> (Gram-negative bacteria), and <i>Candida albicans</i> and <i>Aspergillus niger</i> (fungi). Among the synthesized 1,4-disubstituted 1,2,3-bistriazoles, compounds <b>6a, 6b,</b> and <b>7b</b> displayed excellent antimicrobial potential against most of the tested strains.</p>