Nur77 is expressed in inflamed human and mouse colon tissue and intestinal macrophage populations are similar in healthy colons of WT and Nur77^-/- mice.

<p>Immunohistochemistry for Nur77 was performed on colon sections from a healthy and affected part of the colon from patients (A) with either Crohn’s disease (CD) or ulcerative colitis (UC) and colon sections from WT mice (B) before and after DSS- or TNBS-induced colitis. Representative photomicrographs are shown with original magnification 200x (A), 100x (B). Arrows indicate examples of cells with nuclei positive for Nur77 protein in epithelial cells (black) and inflammatory cells (red). Colonic lamina propria cells were isolated for flow cytometry and macrophages were selected and presented as three different subpopulations (C). Data are presented as mean±SD. Scale bars represent 1mm.