Modelled structure of COX-1 and COX-2.

<p><b>Comparison of modelled structures with their template structures revealed the active sites of located in the enzymes.</b> (A) Membrane binding domain, epidermal growth factor binding domain, peroxidase active site, and cyclooxygenase active site of modeled COX-1 and COX-2 enzymes. Shape of cyclooxygenase active sites are shown in yellow and four helices of membrane binding domains are located just beneath it, represented in red. A heme group was present at the peroxidase active site of COX-2 enzyme. (B) Flurbiprofen (brown) was inherited at the cyclooxygenase active site of COX-1 modelled structure from its template structure (PDB ID: 1CQE). Area of active site is depicted by the use of white dots, yellow mesh surface shows hydrophobic region and green mesh surface shows hydrophilic region of the active site. (C) Diclofenac (cyan) was inherited at the cyclooxygenase active site of COX-2 modelled structure from its template structure (PDB ID: 1PXX). Same colours were used to show the area of active site, hydrophobic region and hydrophilic region of the active site. Green hydrophilic channel in COX-2 was larger than the channel of COX-1 enzyme.