<p>(a) Native, R273C and R273C_T284R, (b) Native, R273H and R273H_T284R, (c) Native, R273H and R273H_S240R.</p
The "genome guardian" protein p53 plays an important role in cancer growth. P53 mutations occur in m...
[[abstract]]The mutation of R273H in the p53 core domain (p53-CD) is one of the most common mutation...
The aim of this thesis was to use biophysical methods to characterise the stabilities and DNA bindin...
<p>(a) Native, R273C and R273C_T284R, (b) Native, R273H and R273H_T284R, (c) Native, R273H and R273H...
<p>(a) Native, R273C and R273C_T284R, (b) Native, R273H and R273H_T284R, (c) Native, R273H and R273H...
<p>(a) Native, R273C and R273C_T284R, (b) Native, R273H and R273H_T284R, (c) Native, R273H and R273H...
<p>Variation of solvent accessible surface area (SASA) of nuclear localization signal residues R31, ...
<p>SASA of the wild type and the mutants is shown as a function of time. (A) The wild type is repres...
<p>The ordinate is SASA (nm<sup>2</sup>), and the abscissa is time (ps). Black, blue, green, violet ...
<p><b>(A)</b> Scheme of intramolecular T.A.<i>T</i> triplex in scDNA. AFM image of sc pA69 plasmid a...
<p>A) Distribution of hot spot mutations on full length p53 (conserved regions marked by cylinders) ...
<p>A) Mutp53 proteins recognize MSP/MST1 site in scDNA differently. Mutp53s and wtp53 were bound to ...
The P53 protein, a cancer-associated transcriptional factor and tumor suppressor, houses a Zn2+ ion ...
<p>(a) Native-DNA complex, (b) R273C-DNA complex, (c) R273H-DNA complex, (d) R273C_T284R-DNA complex...
[[abstract]]The mutations of R248 to Trp and Gln in the core domain (CD) of the p53 protein are some...
The "genome guardian" protein p53 plays an important role in cancer growth. P53 mutations occur in m...
[[abstract]]The mutation of R273H in the p53 core domain (p53-CD) is one of the most common mutation...
The aim of this thesis was to use biophysical methods to characterise the stabilities and DNA bindin...
<p>(a) Native, R273C and R273C_T284R, (b) Native, R273H and R273H_T284R, (c) Native, R273H and R273H...
<p>(a) Native, R273C and R273C_T284R, (b) Native, R273H and R273H_T284R, (c) Native, R273H and R273H...
<p>(a) Native, R273C and R273C_T284R, (b) Native, R273H and R273H_T284R, (c) Native, R273H and R273H...
<p>Variation of solvent accessible surface area (SASA) of nuclear localization signal residues R31, ...
<p>SASA of the wild type and the mutants is shown as a function of time. (A) The wild type is repres...
<p>The ordinate is SASA (nm<sup>2</sup>), and the abscissa is time (ps). Black, blue, green, violet ...
<p><b>(A)</b> Scheme of intramolecular T.A.<i>T</i> triplex in scDNA. AFM image of sc pA69 plasmid a...
<p>A) Distribution of hot spot mutations on full length p53 (conserved regions marked by cylinders) ...
<p>A) Mutp53 proteins recognize MSP/MST1 site in scDNA differently. Mutp53s and wtp53 were bound to ...
The P53 protein, a cancer-associated transcriptional factor and tumor suppressor, houses a Zn2+ ion ...
<p>(a) Native-DNA complex, (b) R273C-DNA complex, (c) R273H-DNA complex, (d) R273C_T284R-DNA complex...
[[abstract]]The mutations of R248 to Trp and Gln in the core domain (CD) of the p53 protein are some...
The "genome guardian" protein p53 plays an important role in cancer growth. P53 mutations occur in m...
[[abstract]]The mutation of R273H in the p53 core domain (p53-CD) is one of the most common mutation...
The aim of this thesis was to use biophysical methods to characterise the stabilities and DNA bindin...
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