<p>(A) Shows the normal p53-DNA interaction, leading to cancer suppression. (B) Illustrates how a DNA-contact mutation results in a reduced p53-DNA affinity, which is a possible cause of cancer. (C) Shows that a rescue mutation can restore the good p53-DNA affinity, and thus give again rise to cancer suppression.</p
The p53 tumor suppressor is a sequence-specific DNA binding protein that activates gene transcriptio...
The p53 tumor suppressor is a sequence-specific DNA binding protein that activates gene transcriptio...
p53 is required for the maintenance of the genomic stability of cells. Mutations in the p53 tumor-su...
<div><p>The tumor suppressor protein p53 can lose its function upon DNA-contact mutations (R273C and...
The tumor suppressor protein p53 can lose its function upon DNA-contact mutations (R273C and R273H) ...
The p53 is a potent tumor suppressor, which becomes activated in response to stress. The activated p...
The p53 is a potent tumor suppressor, which becomes activated in response to stress. The activated p...
The tumor suppressor p53 is the most commonly mutated gene in cancers, with approximately half of al...
The p53 protein plays active roles in the physiological regulation of cell cycle as well as in cance...
Most human cancers contain mutations in the transcription factor p53 and majority of these are misse...
Most human cancers contain mutations in the transcription factor p53 and majority of these are misse...
The tumor suppressor p53 is the most commonly mutated gene in cancers, with approximately half of al...
The mutation of TP53 gene affects half of all human cancers, resulting in impairment of the regulati...
Most human cancers contain mutations in the transcription factor p53 and majority of these are misse...
The tumor-suppressing function of p53 can be affected in a variety of manners. Here, we describe a n...
The p53 tumor suppressor is a sequence-specific DNA binding protein that activates gene transcriptio...
The p53 tumor suppressor is a sequence-specific DNA binding protein that activates gene transcriptio...
p53 is required for the maintenance of the genomic stability of cells. Mutations in the p53 tumor-su...
<div><p>The tumor suppressor protein p53 can lose its function upon DNA-contact mutations (R273C and...
The tumor suppressor protein p53 can lose its function upon DNA-contact mutations (R273C and R273H) ...
The p53 is a potent tumor suppressor, which becomes activated in response to stress. The activated p...
The p53 is a potent tumor suppressor, which becomes activated in response to stress. The activated p...
The tumor suppressor p53 is the most commonly mutated gene in cancers, with approximately half of al...
The p53 protein plays active roles in the physiological regulation of cell cycle as well as in cance...
Most human cancers contain mutations in the transcription factor p53 and majority of these are misse...
Most human cancers contain mutations in the transcription factor p53 and majority of these are misse...
The tumor suppressor p53 is the most commonly mutated gene in cancers, with approximately half of al...
The mutation of TP53 gene affects half of all human cancers, resulting in impairment of the regulati...
Most human cancers contain mutations in the transcription factor p53 and majority of these are misse...
The tumor-suppressing function of p53 can be affected in a variety of manners. Here, we describe a n...
The p53 tumor suppressor is a sequence-specific DNA binding protein that activates gene transcriptio...
The p53 tumor suppressor is a sequence-specific DNA binding protein that activates gene transcriptio...
p53 is required for the maintenance of the genomic stability of cells. Mutations in the p53 tumor-su...
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