Composite comparisons between transcriptomes of <i>N</i>. <i>gonorrhoeae</i> in natural infection vs. growth in CDM.

<p><b>(A)</b> Log values of expression (RPKM) levels are indicated. Expression levels in all 4 cervico-lavage samples were averaged and compared to the average expression levels of the three isolated <i>N</i>. <i>gonorrhoeae</i> strains grown <i>in vitro</i> in CDM supplemented with ferric nitrate (100 μM final concentration). Genes in blue had q-values < 0.05. <b>(B)</b> Functional enrichment of genes showing changes in expression when examining gonococcal transcriptomes during natural infection compared to growth in CDM supplemented with ferric nitrate (100 μM final concentration). Availability of several subject samples permitted statistical analysis and genes were considered to be differentially expressed between two samples if the q value was < 0.05 and the fold change > 2. Blue bars indicate functional enrichment of genes showing increased expression during natural infection <i>in vivo</i> compared to growth in CDM. Red bars indicate functional enrichment of genes showing decreased expression during natural infection <i>in vivo</i> compared to growth in CDM.