Effects of P-188 NF and prednisone on tidal volume/BW in the <i>mdx</i> mouse over time.

<p><i>Mdx</i> mice were treated QD, <i>s</i>.<i>c</i>. with P-188 NF (3 mg/Kg) or prednisone (1 mg/Kg) from age 7 months to 12 months ± 2 weeks. The black line represents wild-type mice (C57BL/10 SnJ) treated with saline. The red line represents <i>mdx</i> mice treated with saline. The blue line represents mice treated with P-188 NF (Panel A) or 1 mg/Kg prednisone (Panel B). Data points are means +/- S.D. N = 11 for <i>mdx</i> 3 mg/Kg P-188 NF at 20 and 22 weeks, N = 12/group for prednisone treatment. Panel A, P < 0.0001 for the overall effect of P-188 NF 3 mg/Kg group vs. <i>mdx</i> saline and wild type saline. The <i>mdx</i> 3 mg/Kg group was also significantly greater than <i>mdx</i> saline at 22 weeks (P < 0.0001). Panel B, P = 0.001 to 0.0001 for <i>mdx</i> 1 mg/Kg prednisone group vs. <i>mdx</i> saline and P < 0.0001 vs. wild type saline. The <i>mdx</i> prednisone group was also significantly greater than <i>mdx</i> saline at 22 weeks (P < 0.0001).