<p><b>(A)</b> Schematic of the matrix contraction assay. From top to bottom, fibroblasts were mixed with a collagen solution that polymerizes into a 3D collagen matrix for 2 h. This mixture was then released from the culture dish and allowed to float in culture medium. Floating collagen lattices were incubated with TGF-β1 for 24 hours to induce fibroblasts contraction, leading to a volume reduction of the collagen lattice. <b>(B)</b> NIH3T3 fibroblasts were transiently transfected with a pool of shRNAs against mouse RECK (shReck) or with a RECK overexpression vector or with an empty vector as control. 24 h post-transfection, fibroblasts were trypsinized and a collagen contraction assay was performed as described in (A). After 24 h, the now ...
<p>Rac inhibitor 50 µM NSC23766 (24 hour treatment) reduced the ability of lesional SSc fibroblasts ...
Fibronectin (FN) is an extracellular matrix glycoprotein that is abundantly expressed by fibroblasts...
Fibronectin (FN) is an extracellular matrix glycoprotein that is abundantly expressed by fibroblasts...
<p><b>(A)</b> Primary fibroblasts cultures derived from skin biopsies of 3 month old WT (skin-Fbs<su...
<p><b>(A)</b> NIH3T3 fibroblasts were transiently transfected with a pool of shRNAs against mouse RE...
<p><b>(A)</b> NIH3T3 fibroblasts and were incubated with TGF-β1 for 24 and 48 h at the indicated con...
<p><b>(A)</b> NIH3T3 fibroblasts were pre-treated for 30 minutes with different inhibitors: TGF-β-RI...
<div><p>Fibroblasts are critical for wound contraction; a pivotal step in wound healing. They produc...
Generation of contractile forces as fibroblasts attach and migrate through collagenous substrates is...
AbstractThe intracellular mechanisms controlling mechano-dependent production of the two extracellul...
Objective - Fibrosis is believed to occur through normal tissue remodeling failing to terminate. Tis...
AbstractThe intracellular mechanisms controlling mechano-dependent production of the two extracellul...
Fibronectin (FN) is an extracellular matrix glycoprotein that is abundantly expressed by fibroblasts...
Fibronectin (FN) is an extracellular matrix glycoprotein that is abundantly expressed by fibroblasts...
Fibronectin (FN) is an extracellular matrix glycoprotein that is abundantly expressed by fibroblasts...
<p>Rac inhibitor 50 µM NSC23766 (24 hour treatment) reduced the ability of lesional SSc fibroblasts ...
Fibronectin (FN) is an extracellular matrix glycoprotein that is abundantly expressed by fibroblasts...
Fibronectin (FN) is an extracellular matrix glycoprotein that is abundantly expressed by fibroblasts...
<p><b>(A)</b> Primary fibroblasts cultures derived from skin biopsies of 3 month old WT (skin-Fbs<su...
<p><b>(A)</b> NIH3T3 fibroblasts were transiently transfected with a pool of shRNAs against mouse RE...
<p><b>(A)</b> NIH3T3 fibroblasts and were incubated with TGF-β1 for 24 and 48 h at the indicated con...
<p><b>(A)</b> NIH3T3 fibroblasts were pre-treated for 30 minutes with different inhibitors: TGF-β-RI...
<div><p>Fibroblasts are critical for wound contraction; a pivotal step in wound healing. They produc...
Generation of contractile forces as fibroblasts attach and migrate through collagenous substrates is...
AbstractThe intracellular mechanisms controlling mechano-dependent production of the two extracellul...
Objective - Fibrosis is believed to occur through normal tissue remodeling failing to terminate. Tis...
AbstractThe intracellular mechanisms controlling mechano-dependent production of the two extracellul...
Fibronectin (FN) is an extracellular matrix glycoprotein that is abundantly expressed by fibroblasts...
Fibronectin (FN) is an extracellular matrix glycoprotein that is abundantly expressed by fibroblasts...
Fibronectin (FN) is an extracellular matrix glycoprotein that is abundantly expressed by fibroblasts...
<p>Rac inhibitor 50 µM NSC23766 (24 hour treatment) reduced the ability of lesional SSc fibroblasts ...
Fibronectin (FN) is an extracellular matrix glycoprotein that is abundantly expressed by fibroblasts...
Fibronectin (FN) is an extracellular matrix glycoprotein that is abundantly expressed by fibroblasts...