RAGE signaling increases V1R/Gq-dependent calcium signaling.

<p>A, Typical calcium measurement kinetics obtained with FURA-2 and histograms indicate (B) basal calcium levels, (C) Gq-dependent calcium release and (D) calcium entry in A7r5 cells stimulated for 24 hours with PBS, 1 mg/ml AGE-HSA or 1 mg/ml CML-HSA and challenged with 2 nM AVP. Each bar represents 9–12 independent experiments. * <i>p</i> < 0.05 compared with PBS using one-way ANOVA followed by Dunnett’s post-test.