Temporal variation in mtDNA/nDNA ratio during pregnancy, at delivery and postpartum for the HIV+ cohort.

<p>A) mtDNA/nDNA ratio in HIV- women (n = 42), HIV+ women who initiated cART prior to conception (n = 17) and continued throughout pregnancy, and HIV+ women who initiated cART during pregnancy (n = 46) at each sample time point (13–22 weeks, 23–30 weeks, 31–40 weeks, delivery, 6 weeks postpartum); mtDNA/ nDNA ratio among HIV+ women (n = 63) for the significant variables of (B) time of visit (13–22 weeks, 23–30 weeks, 31–40 weeks, delivery, 6 weeks postpartum), where the horizontal line in the boxplots indicates the median value, boxes represent the interquartile range, whiskers indicate 1.5 times the interquartile range, while points indicate outliers; (C) CD4 nadir, where the best-fit line from the mixed-effects model is shown.