Palladacycle-Catalyzed Carbonylative Suzuki–Miyaura Coupling with High Turnover Number and Turnover Frequency

This work reports the carbonylative Suzuki–Miyaura coupling of aryl iodides catalyzed by palladacycles. More importantly, the palladacycles have been used to generate high turnover numbers (TON’s) and turnover frequencies (TOF’s). A range of aryl iodides can be coupled with arylboronic acids, generating TON’s in the range of 10⁶ to 10⁷ and TOF’s in the range of 10⁵ to 10⁶ h^–1. Comparison of the palladacycles with a conventional palladium source shows their superiority in generating high TON’s and TOF’s