Buchwald–Hartwig Amination of (Hetero)Aryl Tosylates Using a Well-Defined N‑Heterocyclic Carbene/Palladium(II) Precatalyst

The cross-coupling of aryl tosylates with amines and anilines was achieved by using for the first time a Pd-NHC system based on the popular Pd-PEPPSI precatalyst platform in which the anchoring imidazol-2-ylidene ligand IPr^(NMe₂)₂ incorporates two dimethylamino groups as backbone substituents enhancing both the electronic and steric properties of the carbene. The system optimization and its application scope are disclosed