Efficient DT-induced pDC depletion does not influence aortic root and carotid lesion size after partial carotid artery ligation, but affects plasma Il-6 levels after 5 weeks of HFD and one week DT administration.

<p>(A) H&E staining of representative cryosections of the ligated left carotid artery (scale bar = 200 μm), quantification of plaque area (% of carotid lumen). (B) Aortic root lesions with Oil Red O⁺ area in % of aortic root surface (scale bar = 500 μm) and (C) plasma lipid levels of cholesterol and triglycerides (mg/dL) of <i>Apoe</i>^{<i>−/−</i>} (control) and <i>Apoe</i>^{<i>−/−</i>}<i>BDCA2 DTR</i> mice (pDC depleted) after 5 weeks of HFD and one week i.p. DT administration. Graphs represent mean±SD; n = 6 to n = 12. Mann-Whitney test. *<i>P</i><0.05