PARP-1 Inhibition Is Neuroprotective in the R6/2 Mouse Model of Huntington’s Disease - Fig 1

<p>In (<b>A</b>) the survival is described by means of a Kaplan-Meier curve. R6/2 mice treated with INO-1001 showed a mean survival time that was significantly (<i>P</i><0,0001) longer than that of R6/2 mice treated with saline. (<b>B</b>) INO-1001 effects on wild type and R6/2 mice weight. A three-way ANOVA shows a statistically significant effect of genotype (F(1,18) = 321,16;<i>P</i><0,0001),treatment(F(1,18) = 9,02;<i>P</i><0,0076),time(F(9,162) = 27,74;<i>P</i><0,0001) and a genotype X treatment X time interaction (F(9,162) = 7,52;<i>P</i><0,0001) in R6/2 mice treated with INO-1001(<b>C</b>). Hind-limb clasping phenotype in R6/2 mice treated with INO-1001. Data analysis indicates a statistically significant effect of treatment and age. INO-1001 treated mice showed significantly less clasping at week 10,11,12 and 13 (<b>D</b>)(*** <i>P</i><0,001).