The commonly shared top 10 signaling pathways between RA and T2D in details.

<p><b>A</b>: completement system; <b>B</b>: agranulocyte adhesion and diapedesis; <b>C</b>: granulocyte adhesion and diapedesis; <b>D</b>: IL-8 signaling; <b>E</b>: differential regulation of cytokine production in macrophages and T helper cells by IL-17A and IL-17F; <b>F</b>: Natural killer cell signaling; <b>G</b>: differential regulation of cytokine production in intestinal epithelial cells by IL-17A and IL-17F; <b>H</b>: acute phase response signaling; I: crosstalk between dendritic cells and natural killer cells; <b>J</b>: OX40 signaling pathways. <b>Red nodes</b>: up-regulated DEGs in RA <i>vs</i>. control group; green nodes: down-regulated DEGs in RA <i>vs</i>. control group; <b>violet circles</b>: up-regulated DEGs in T2D <i>vs</i>. control group; <b>blue circles</b>: down-regulated DEGs in T2D <i>vs</i>. control group.