A lower ITGA2 protein level was observed in primary cancers compared to adjacent non-cancerous samples.

<p>(A) Representative images from IHC staining of ITGA2 in lymph node (LN)-positive and LN-negative breast cancers. N: adjacent non-cancerous samples; T: primary cancers; M: lymph node metastases. Images were captured at 400× magnification. (B) ITGA2 protein level was plotted in N, T and M. (C) ITGA2 protein level was shown as a box plot using IHC scores. The horizontal lines represent the median; the bottom and top of the boxes represent the 25^th and 75^th percentiles, respectively, and the vertical bars represent the range of the data. (D) ITGA2 protein level was plotted between LN-negative and positive primary breast cancers as described in (B). (E) ITGA2 protein level was shown as a box plot between LN-negative and positive primary breast cancers as described in (C).