Effect of treatment with liraglutide and linagliptin on body weight and glycaemic control in DIO hamsters.

<p>(A) Body weight change (% of day 0) of obese hyperlipidemic hamsters treated for 26 days with vehicle (PO, QD), liraglutide (0.2 mg/kg, SC, BID) or linagliptin (3.0 mg/kg, PO, QD). Mean weight on day 0 was 185.6 ± 18.29 g. Absolute weight loss for the liraglutide group was 31.8 ± 14.6 g. (B, C) blood glucose and (D, E) plasma insulin responses to an OGTT following 26 days of treatment with vehicle (PO, QD), liraglutide (0.2 mg/kg, SC, BID) or linagliptin (3.0 mg/kg, PO, QD). Hamsters were semi-fasted 16 h before the OGTT. Drugs were administered 45 min prior to the oral glucose load (2g/kg). Hamsters included in the study were fed a HPFS diet with 0.5% cholesterol supplemented for 12 weeks before initiation of the study. Values are means ± SEM (n = 6 per group; ^aP<0.05 for liraglutide vs. vehicle group, ^bP<0.05 for linagliptin vs. vehicle group, (** indicates <i>P</i><0.01).