Immunological correlates of viremia control.

<p>Correlation of phagocytic activity (expressed as phagocytosis score/background phagocytosis) of gp140-immunized macaques using gp140 targets 2 weeks post-second Env boost (wk 53) with peak viral load (A). Correlation of phagocytic activity of all macaques 2wkpi with peak viral load (B). Correlation of peripheral Env_smH4-specific CD8⁺_TMT cells (% CD8⁺_TM T cells expressing IL-2, IFN-γ, and TNF-α) in all animals with reduced peak viral load (C) and chronic viremia (median over weeks 8–24) (D). Correlation of Env_smH4-specific CD8⁺_TM T cells (% CD8⁺_TM T cells expressing IL-2, IFN-γ, and TNF-α) 2wkpi in gp140-immunized macaques with (E) peak viral load, (F) acute viral load (geometric mean over weeks 1–6), and (G) chronic viremia (median over weeks 8–24). One gp140-immunized female macaque remained uninfected so is not included in these correlations with viral load. Due to the large number of macaques only half of the macaques in each group were assessed for CD8⁺_TM T cell SIV_smH4 Env-specificity.